We would like to thank Steven Carter, Executive Director of the International Schizophrenia Foundation, for kind permission to use material that originally appeared in the Journal of Orthomolecular Medicine. I am indebted to the late Mrs. Charlotte Kaufman for gracious encouragement and permission to publish correspondence, private notes, and other writings of her husband, Dr. William Kaufman, thus making his important work widely available to the public. We value the specialized input from Dr. Robert G. Smith, Research Associate Professor in the Department of Neuroscience, University of Pennsylvania. Thanks to all the contributors to the Orthomolecular Medicine News Service, some articles of which are incorporated in this book. A special thanks to Dr. W. Todd Penberthy, for reading and making expert suggestions to the text.